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KMID : 0384119910110010153
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Korean Journal of Clinical Pathology
1991 Volume.11 No. 1 p.153 ~ p.160
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A Study on Activity of Purine Nucleoside Phosphorylase (PNP) and Natural Killer (NK) Cells in Patients with Cancer
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T. J. Yoon
Y. S. Lee/S. H. Lee/E. Y. Lee/S. H. Kim
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Abstract
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To elucidate alteration of the activity of purine nucleoside phosphorylase (PNP) and natural killer (NK) cells of the peripheral blood lymphocytes in cancer patients, We examined the PNP and NK cell activity of the peripheral blood lymphocytes in 5 cases of colon cancer, 5 cases of hepatocellular carcinoma, 8 cases of lung cancer and 5 cases of uterine cervical cancer as well as 23 cases of adult healthy subjects as controls. Diagnoses were confirmed histopathologically in all the patients. All blood samples were obtained from veins of the patients and control. subjects in Pusan National University Hospital during the period of January to August, 1990. The results obtained were summarized as follows : 1. The activity of PNP was significantly increased in colon cancer, hepatocellular carcinoma, lung cancer and uterine cervical cancer as compared with adult healthy subjects. 2. The activity of NK cells was significantly decreased in colon cancer, hepatocellular carcinoma, lung cancer and uterine cervical cancer, as compared with adult healthy subjects. 3. No significant correlation between PNP activity and NK activity was found in adult healthy subjects, colon cancer, hepatocellular carcinoma, lung cancer and uterine cervical cancer. On the basis of the results, it can be suggested that the PNP activity was increased and the NK cell activity was decreased in cancer patients.
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